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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
unsuitable test system

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
application of Propionaldehyde intra peritoneal
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: Ivanovas, Kisslegg/Allgäu
- Weight at study initiation: female: 24.6 g; male: 26.8 g

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Details on exposure:
no data
Doses:
373, 548, 664, 731, 805 mg/kg b.w.
No. of animals per sex per dose:
5 per sex per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 724 mg/kg bw
Based on:
test mat.
Mortality:
see table
Clinical signs:
Dyspnea, apathy, partly prone position, partly tremor and staggering
Body weight:
female: d1: 24.8g; d5: 27.4g; d7: 28.0g
male: d1: 27.4g; d5: 32.2g; 34.2g
Gross pathology:
no precipitation, no agglutination

Any other information on results incl. tables

Mortality:

died within
Dose (mg/kg) animal/sex 1 hour 24 hours 48 hours 7 days
805 5M 0/5 1/5 2/5 5/5
5F 0/5 2/5 2/5 5/5
731 5M 0/5 0/5 0/5 0/5
5F 0/5 0/5 0/5 0/5
664 5M 0/5 1/5 2/5 3/5
5F 0/5 0/5 0/5 0/5
548 5M 0/5 0/5 0/5 0/5
5F 0/5 0/5 0/5 0/5
373 5M 0/5 0/5 0/5 0/5
5F 0/5 0/5 0/5 0/5

Applicant's summary and conclusion