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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Human liver aldehyde dehydrogenase: partial purification and properties
Author:
Blair A.H., Bodley F.H
Year:
1969
Bibliographic source:
Canadian journal of biochemistry vol 47

Materials and methods

Objective of study:
metabolism
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
extraction of aldehyde dehydrogenase from human liver
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Propionaldehyde
- Analytical purity: reagent grade
distilled under nitrogen before use
Radiolabelling:
no

Test animals

Species:
human
Strain:
other: not applicable
Sex:
not specified

Administration / exposure

Route of administration:
other: not applicable
Vehicle:
other: not applicable
Duration and frequency of treatment / exposure:
no data
Doses / concentrations
Remarks:
Doses / Concentrations:
0.05, 0.03, 3.0 mM propionaledhyde
No. of animals per sex per dose:
not applicable: in vitro test
Control animals:
no
Positive control:
Acetaldehyde

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
not applicable
Details on distribution in tissues:
not applicable
Details on excretion:
not applicable

Metabolite characterisation studies

Metabolites identified:
not measured

Any other information on results incl. tables

The rate of oxidation for propionaldehyde is comparable to acetaldehyde when tested in vitro at substrate concentrations between 0.5 and 3.0 mM using partially purified human liver aldehyde dehydrogenase

Relative rates of oxidation of aldehydes by human liver aldehyde dehydrogenase:

   Aldehyde concentration      
 substrate 0.05 mM   0.03 mM  3.0 mM
 Acetaldehyde  0.82  0.92  1.0*
 Propionaldehyde 0.90   1.0  1.1

(*: Rate with 3.0 mM acetaldehyde set equal to 1.0 as standard)

Applicant's summary and conclusion