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EC number: 217-983-9 | CAS number: 2031-67-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 3 Sept to 17 Sept 1991
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- the determination of the particle size failed, presumably because the substance was emitted mainly as vapour
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- It was technically not possible to determine the particle size, necropsy was performed but a detailed description of its extend is missing.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Triethoxy(methyl)silane
- EC Number:
- 217-983-9
- EC Name:
- Triethoxy(methyl)silane
- Cas Number:
- 2031-67-6
- Molecular formula:
- C7H18O3Si
- IUPAC Name:
- triethoxy(methyl)silane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG, SPF-Zucht, GERMANY
- Age at study initiation: 8-10 wk
- Weight at study initiation: males 188 (184-191) g; females 190 (185-200) g
- Housing: 1/plastic cage
- Diet: standard diet ad libitum
- Water: drinking water ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 50 +/- 20
- Photoperiod (hrs dark / hrs light): 12h/ 12 h
IN-LIFE DATES: From: 1991-09-03 To: 1991-09-17
Administration / exposure
- Route of administration:
- other: aerosol/vapour
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
[from report in German]
- Exposure apparatus: cylindrical plastic cages housed in stainless steel inhalation chamber
- Exposure chamber volume: total volume 60 L
- Method of holding animals in test chamber: rats were fitted into test tubes with a coned end reaching into the test chamber
- Source and rate of air: 800 L/h
- Method of conditioning air: air was led at a constant pressure of 4 bar into a nozzle and through separators and filters
- System of generating particulates/aerosols: test substance was injected contineously into the air flow in the nozzle, primary aerosol built in a four-necked round-bottom flask, through a riser-pipe secondary arosol (smaller particle size) reached the test chamber
- Method of particle size determination: The determination of the particle size was not possible as teh substance was mainly emitted as gas.
TEST ATMOSPHERE
- Brief description of analytical method used: gas chromatography with FID detector
- Samples taken from breathing zone: yes
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: not given
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): not given
- Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 13.5 mg/L
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations 2/day; weights on Days 0, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: no other examinations - Statistics:
- Single exposure concentration - no statistics presented.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 13 500 mg/m³ air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: Taking into account that the measured concentration (13.5 mg/L) greatly exceeds the saturated vapour concentration (7.19 mg/L), the exposure atmosphere is considered a mixture of saturated vapour and aerosol.
- Mortality:
- 1/5 males; 0/5 females
- Clinical signs:
- other: Ataxia, irregular respiration, stupor, altered gait, prostration, tonic convulsions, trembling and reduced spontaneous activity were seen in both sexes during the 14-day observation period.
- Body weight:
- No treatment-related effect identified.
- Gross pathology:
- 1/5 males had dark red, patchy lungs. [The extent of examination is unclear.]
Any other information on results incl. tables
Table 1: Concentration and mortality per animals treated
Analytical Conc. (mg/L) |
Mortality (dead/total) |
||
Males |
Females |
Combined |
|
13.5 |
1/5 |
0/5 |
1/10 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulations (EC) No 1272/2008
- Conclusions:
- In an acute inhalation (vapour) study conducted in compliance with OECD 403 and GLP (reliability score 1) in which rats were exposed to triethoxy(methyl)silane at a concentration of 13.5 mg/L for four hours only one animal from a total of ten died. The LC50 thus is greater than 13.5 mg/L (highest achievable dose).
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