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EC number: 219-147-9 | CAS number: 2373-38-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
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- Density
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
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- Additional toxicological data

Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
21-day EC10: 9.0 mg/L
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 9 mg/L
Additional information
In the Klimisch 1 GLP study from Eckenstein (2014) the chronic toxicity of Butanedioic acid, sulfo-, 1,4-bis(2-ethylhexyl)ester, sodium salt on Daphnia magna was determined in an 21 day semi-static test according to OECD 211. The test was performed with concentrations of 0.55, 1.1, 2.2, 4.4, 8.8, 11 and 22 mg/L and a blank control. Ten replicates with 1 Daphnia each were set up. After 21 days 0, 10, 0, 0, 0, 10, 30 and 100% mortality was observed in the control and at nominal test concentrations of 0.55, 1.1, 2.2, 4.4, 8.8, 11 and 22 mg/L, respectively. The reproduction per parent daphina was 137.0 (10), 135.6 (9*), 139.0 (10), 140.4 (10), 133.8 (10), 141.4 (9*), 107.4 (10) and 0 (10) living offspring per parental animal (number of parental daphinds used to calculate the mean are given in brackets). The measured concentrations of the test item in the test media of the test concentrations were between 94 and 110% of the nominal values in the freshly prepared test solutions and between 86 and 111% in the aged test solutions at the end of the renewal interval. Therefore, the biological results were based on nominal concentrations. The EC10 for reproduction is 9.8 mg/L, the EC10 for mortality is 9.0 mg/L. Length was not affected. For the risk assessment, the more conservative EC10, i.e., the EC10 for mortality was used.
Read across is justified since there is a general trend of decreasing ecotoxicity with decreasing C-chain length and the source substance has a longer C-chain. Furthermore, the acute toxicity of the target substance was lower than the ecotoxicity of hte source substance. Further information is provided in the read across argumentation.
The result is considered relevant and reliable for the risk assessment.
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