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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Specific investigations: other studies

Currently viewing:

Administrative data

Endpoint:
endocrine system modulation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
22.05.2012 - 25.05.2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: recent study conducted according to reliable in-house protocol

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: according to P. Sohoni and J.P. Sumpter (1998)
Principles of method if other than guideline:
The aim of the study was to determine the androgenic and antiandrogenic potential of (4-nonylphenoxy) acetic acid. The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Andregenie as weil as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
GLP compliance:
no
Type of method:
in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
(4-nonylphenoxy)acetic acid
EC Number:
221-486-2
EC Name:
(4-nonylphenoxy)acetic acid
Cas Number:
3115-49-9
Molecular formula:
C17H26O3
IUPAC Name:
2-(4-nonylphenoxy)acetic acid
Details on test material:
- Name of test material: (4-nonylphenoxy) acetic acid
- Physical state: Liquid, yellow to brown
- Analytical purity: >99%
- Storage condition of test material: Room temperature

Administration / exposure

Vehicle:
DMSO

Results and discussion

Details on results:
ln this study, the test substance (4-nonylphenoxy) acetic acid showed no androgenic activity in comparison to dihydrotestosterone. ln this study, the test substance (4-nonylphenoxy) acetic acid showed clear antiandrogenic activity from about 10-5 mol/L in comparison to hydroxyflutamide. No cytotoxicity was observed.

Applicant's summary and conclusion