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Neurotoxicity

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Description of key information

The following study has been submitted to address the neurotoxicity endpoint:
EFSA (2004) Opinion of the Scientific Panel on Contaminants in the Food Chain on a request from the Commission to assess the health risks to consumers associated with exposure to organotins in foodstuffs. The EFSA Journal 1002: 1-119
As the study is secondary source it has been allocated a Klimisch score of 4.

Key value for chemical safety assessment

Additional information

The European Food Safety Authority (EFSA) in the Option of the Scientific Panel on Contaminants in the Food Chain on request from the Commission to assess the risks to consumers associated with exposure to organotins in foodstuffs (2004),considered evidence of neurotoxicity and concluded that, while there is clear-cut evidence of neurotoxicity with regard to trimethyl tin, triethyltin and triphenyltin, other tri- and also di-alkyltins are less or - possibly - not neurotoxic at all. There is a lack of systematic experimental data showing NOAELs. Dibutyltin shows the same biochemical effect (decoupling of oxidative phosphorylation). With regard to risk assessment NOAELs cannot be derived from the studies. It is however clear from available studies, that any potential neurotoxicity is not the most sensitive marker of dibutyltin toxicity.

Justification for classification or non-classification