Registration Dossier

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Long-term toxicity studies:

Long-term toxicity studies were used preferentially to acute studies as they provide a more reliable indication of toxicity to ecological systems.

Holcombe et al, 1995, was selected as the key study for long-term toxicity to fish as it was of adequate reliability and was conducted in the last 15 years. Holcombe et al, 1995, reported a 28 day NOEC value of 5.81mg/l based upon growth rate.

Adams et al, 1989, was conducted on Octopuses using a novel testing methodology. This study was selected as the key study for long-term toxicity to aquatic invertebrates as it presents a 3 -hour exposure period on a suitable model organism with an observation battery designed to look at both toxic and sub-toxic effects. The 3-hour LC100 value reported was 100mg/l based upon mortality.

Acute toxicity:

For examination of intermittent release and other acute effects on ecologucal systems acute toxicity studies were considered to provide sufficiently reliable information.

The key studies for acute toxicity to fish, aquatic invertebrates, algae and micro-organisms were all conducted according to recognised testing guidelines and awarded reliability score of 1 according to the criteria of Klimisch et al, 1997. The results of these key studies are reported in the following table:

Summary results of acute toxicity to aquatic species.

Endpoint dose-descriptor value and unit of measurement
Acute toxicity to fish 96-hour LC50 1.13 mg/l
Acute toxicity to aquatic invertebrates 48-hour EC50 11.61 mg/l
Toxicity to Algae and cyanobacteria 72-hour EC50  25.94 mg/l
Toxicity to micro-organisms 3-hour EC50 >1000 mg/l