Registration Dossier

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Annex V,B3
GLP compliance:
yes
Limit test:
yes

Test animals

Species:
other: Rat (Wistar)

Administration / exposure

Type of coverage:
occlusive
Vehicle:
other: N/A
Duration of exposure:
24 h

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 4; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
None
Gross pathology:
Effects on organs:
None
Other findings:
Signs of toxicity (local):
Desquamation and/or scabbing in four males and two
females.Desquamation still apparent in one male at
termination on day 15

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU