Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Materials and methods

Objective of study:
toxicokinetics
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
BPS-MAE
IUPAC Name:
BPS-MAE
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Radiolabelling:
no

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
There is limited evidence that the test substance may be absorbed via the gastro-intestinal tract but there was no evidence of absorption by the dermal route. There was alsolimited evidence of systemic distribution but no evidence of distribution to the central nervous system.  The kidneys may be a site of metabolism and/or excretion. In addition the results of the In vitro mammalian chromosome test in the presence of S-9 mix indicates that the liver may be capableof metabolising this test substance.  There was no evidence of bioaccumulation.