Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Additional information

Repeated dose exposure to trichloroethylene may result in toxicity effects on CNS, liver and kidney.


The following NOAELs are identified in the EU Risk Assessment Report for trichloroethylene (EU RAR, 2004):


NOAEL =100 ppm (inhalation) –effects on kidney

NOAEL > 50 ppm (inhalation) –effects on CNS in humans

NOAEL =50 mg/kg bw (oral exposure) –effects on kidney and liver in experimental animals.

Justification for classification or non-classification