Registration Dossier

Administrative data

Endpoint:
bioaccumulation: aquatic / sediment
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: US EPA accepted QSAR method for organic chemicals properties assessment
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: QSAR
Principles of method if other than guideline:
USEPA (EPI
Suite v.4.00)
GLP compliance:
no
Remarks:
not applicable to QSAR models

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Overview of studies on aquatic bioaccumulation oftrichloroethylene

 

Method

 

Results

Remarks

Reference

QSAR estimate

BCFBAF v.3.00

Log BCF =1.26;

BCF =18.4 L/kg wet wt (regression-based estimate)

 

Biotransformation half-life =1.12 days (normalized to 10 g fish)

 

Log BAF =1.37

BAF =23.7 L/kg wet-wt

(Arnot-Gobas upper trophic)

2 (reliable with

restrictions)

 

key study

 

(Q)SAR

USEPA (EPI

Suite v.4.00)

Applicant's summary and conclusion

Conclusions:
Generally, a BCF/BAF in fish of ≥ 500 is indicative of the potential to bioconcentrate for classification purposes in accordance with CLP/GHS criteria. The BCF/BAF values estimated for trichloroethylene are well below the cut-off values for bioaccumulation. Therefore, trichloroethylene is not likely to bioaccumulate in aquatic organisms.