Registration Dossier

Environmental fate & pathways

Biodegradation in water: screening tests

Administrative data

Endpoint:
biodegradation in water: screening tests
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: US EPA accepted QSAR method for organic chemicals properties assessment
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2009

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: QSAR
Principles of method if other than guideline:
BIOWIN v4.10
GLP compliance:
no
Remarks:
not applicable to QSAR models

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

Overview of estimated data for biodegradation of trichloroethylene in water

 

Method

 

Results

Remarks

Reference

QSARs

Does not biodegrade fast

Predicted with BIOWIN1 (Linear Model Prediction)

EPI Suite

(v.4.00) software

QSARs

Does not biodegrade fast

Predicted with BIOWIN2 (Non-Linear Model Prediction)

EPI Suite

(v.4.00) software

QSARs

Weeks-Months

Predicted with BIOWIN3 (Ultimate Biodegradation Timeframe)

EPI Suite

(v.4.00) software

QSARs

Days –Weeks

Predicted with BIOWIN4 (Primary Biodegradation Timeframe)

EPI Suite

(v.4.00) software

QSARs

Does not biodegrade fast

Predicted with BIOWIN5 (MITI Linear Model Prediction)

EPI Suite

(v.4.00) software

QSARs

Does not biodegrade fast

Predicted with BIOWIN6 (MITI Non-Linear Model Prediction)

EPI Suite

(v.4.00) software

QSARs

Biodegrades Fast

Predicted with BIOWIN7

(Anaerobic Model Prediction)

EPI Suite

(v.4.00) software

QSARs

Ready Biodegradability: NO

Ready Biodegradability Prediction

EPI Suite

(v.4.00) software

Applicant's summary and conclusion

Conclusions:
Overall ready biodegradability prediction provided by a number of BIOWIN (v.4.10) models suggests the trichloroethylene is not ready biodegradable in the environment.