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EC number: 219-397-9 | CAS number: 2431-50-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication meeting basic scientific principles
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- only 4 animals per dose, only 15 min. exposed instead of 4 hours,
- Principles of method if other than guideline:
- The sensory irritation potential of several nasal tumours inducing chemicals were tested in an acute inhalation exposure experiment with rats.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,3,4-trichlorobut-1-ene
- EC Number:
- 219-397-9
- EC Name:
- 2,3,4-trichlorobut-1-ene
- Cas Number:
- 2431-50-7
- Molecular formula:
- C4H5Cl3
- IUPAC Name:
- 2,3,4-trichlorobut-1-ene
- Details on test material:
- - Name of test material (as cited in study report): 2,3,4-Trichloro-1-butene
- Analytical purity: > 99%
- Other: Source: E.I. Du Pont, Wilmington, DE, USA.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Crl-CD
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratory, North Wilmington, DE, USA
- Age at study initiation: 8 weeks
- Weight at study initiation: 232-277 g
- Fasting period before study: no data
- Housing: in pairs in stainless-steel wire-mesh cages
- Diet (e.g. ad libitum): Purina Certified Rodent Chow no. 5002, Ralston Purina, St. Louis, MO, USA)
- Water (e.g. ad libitum): yes
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: :no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- head only
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: 23 L rectangular polymethylmethacrylate chamber for four animals
- Exposure chamber volume: 1.5 L inner compartment for the head-only exposure of 1 animal. Airflow to the inner compartment was turned off, the
compartment was opened to the larger chamber and the 15-min test exposure began. This design enabled the rats to be essentially instantaneously exposed to the equilibrated atmosphere (initial air concentration when inner compartment is opened ts 98.3% of desired).
- Method of holding animals in test chamber: restrainer
- System of generating vapour: Atmosphere was generated by directing a stream of dry nitrogen through an impinger containing 5 to 50 ml of the liquid. The resultant vapours were diluted with houseline air prior to entry into the exposure chamber.
TEST ATMOSPHERE
- Brief description of analytical method used:
- Samples taken from breathing zone: yes
Atmospheric samples were collected every 2-3 min using gas-tight syringes. These samples were analysed on a Hewlett-Packard Model 5710A gas chromatograph (Palo Alto, CA) equipped with a flame-ionization detector. The column used was a 6 ft by 0.08 in. (ID) glass coil packed with 10% SE30 on 80/100 mesh Chromosorb® W. The test substance was chromatographed at 200°C.
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: not applicable
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): not applicable
CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration:
1.5 ppm (6 hr/day, 5 days/wk) produced nasal tumours in rats (see 7.7, 4, Reuzel, 1981, rat, IUC 4) - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- GC with flame-ionization detector
- Duration of exposure:
- 15 min
- Concentrations:
- 0.161, 0.298, 0.380, 0.624 mg/L
(24.3, 45.2, 57.6, 94.3 ppm) - No. of animals per sex per dose:
- 4 animals of unspecified sex were used per dose.
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 24 hours
The respiratory rate was measured during the exposure time of 15 minutes and during recovery of 5 minutes.
The body weight was measured 24 hours after exposure.
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- other: RD50 (concentration needed to produce a 50% respiratory rate depression)
- Effect level:
- 0.38 mg/L air
- Remarks on result:
- other: (58.1 ppm). For comparison: Lowest dose producing nasal tumours: 1.5 ppm
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 0.624 mg/L air
- Exp. duration:
- 15 min
- Remarks on result:
- other: (94.3 ppm) Lacrimation, clear nasal discharge and salivation observed
- Sex:
- not specified
- Dose descriptor:
- other:
- Effect level:
- <= 0.38 mg/L air
- Exp. duration:
- 15 min
- Remarks on result:
- other: (57.6 ppm). No clinical signs of systemic toxicity observed.
- Mortality:
- not observed
- Clinical signs:
- other: Lacrimation, clear nasal discharge and salivation occurred only at the highest dose of 0.624 mg/L (94.3 ppm). No clinical signs of toxicity were seen at 0.161, 0.298 and 0.380 mg/L.
- Other findings:
- The RD50-value (concentration needed to produce a 50% respiratory rate depression) was 0.384 mg/L (58.1 ppm); Depression in respiratory rate occurred at all levels: The average % decrease in respiratory rate was 28, 43, 54 and 69 % at 0.161, 0.298, 0.380 mg/L and 0.624 mg/L test substance concentration.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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