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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes
Limit test:
no

Test material

Constituent 1
Reference substance name:
81485-04-3
EC Number:
617-238-1
Cas Number:
81485-04-3
IUPAC Name:
81485-04-3
Constituent 2
Reference substance name:
2-Chloro-3-(2-chloro-ethyl)-[1,3,2]oxazaphosphinane 2-oxide
IUPAC Name:
2-Chloro-3-(2-chloro-ethyl)-[1,3,2]oxazaphosphinane 2-oxide
Details on test material:
Batch No. 031920 April 3 1991 - from Quality Control, Bielfeld
99.8% pure Stability confirmed by study sponsor

Test animals

Species:
rat
Strain:
other: Bor : WISW (SPFCpb)
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: WInkelmann Versuchstrierzucht GmbH & CO. KG
- Age at study initiation: Males and Females 9-10 weeks
- Weight at study initiation: Males 150-208 gm, Females 133-160 gm
- Fasting period before study: 16 hours
- Housing:
- Diet: ad libitum Water: ad libitum):
- Acclimation period: 5 g days minimum


ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-23
- Humidity (%): 45-70
- Photoperiod: 12 hrs dark / 12 hrs light


IN-LIFE DATES: From: 25th June To: 16 July 1991

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
peanut oil
Details on oral exposure:
- Concentration in vehicle: 46.4; 100; 215
- Amount of vehicle (if gavage):21.5; 21.5, 21.5
Doses:
Males - 1000, 2150 or 4640 mg/kg
Females - 464, 1000 or 2150 mg/kg
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
2 118 mg/kg bw
95% CL:
> 1 054 - 4 226
Sex:
female
Dose descriptor:
LD50
Effect level:
1 474 mg/kg bw
95% CL:
739 - 4 050
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 711 mg/kg bw
95% CL:
1 240 - 2 447

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 = 1711 mg/kg
Executive summary:

Isophamchloride was studies for acute oral toxicity after single oral administration in rats. The test substance was suspended in peanut oil and administered by garage. The dose range was 1000 mg/kg to 4640 mg/kg in males and 464 to 2150 mg/kg in females.

The LD 50 values were Males - 2118 mg/kg Females 1474 mg/kg and for males and females 1711 mg/kg.