Registration Dossier
Registration Dossier
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EC number: 457-320-2 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
In an activated sludge respiration inhibition test, the NOELR was 100 mg/L (nominal loading rate), the highest concentration tested.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
No toxicity to microorganisms studies are available for EC# 457-320-2; however, one is available for the structurally and chemically similar substance, EC# 434-650-5: an activated sludge respiration inhibition test, conducted to GLP and in accordance with OECD Test Guideline 209.
Due to the poor water solubility of the test substance, aliquots calculated to nominally provide concentrations of 1, 10 or 100 mg/L were dissolved in tetrahydrofuran, coated over the inside surfaces of glass beakers and the solvent evaporated under nitrogen. The final volume of the incubation mixture was: 200 ml activated sludge, 16 ml synthetic sewage and 284 ml dechlorinated tap water.
There was no evidence of an inhibitory effect of the test material on the respiration rate, therefore an EC50 could not be establised. The positive control reduced the respiration rate in a dose-related manner, demonstrating the validity of the test.
In view of the structural and chemical similarities, it is considered that the results of this study can be used for read-across to EC# 457-320-2.
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