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EC number: 425-180-1 | CAS number: 66170-10-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
A oral and a dermal acute toxicity study were conducted with Sodium ascorbyl phosphate. Both limit studies showed no mortality, no body weight change and only very weak transient clinical symptoms.
No acute toxicity studies for inhalative administration are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
Oral route:
In an acute oral toxicity study (BASF AG, 1997), one group of fasted, young adult Wistar rats (5/sex) were given a single oral dose of Sodium Ascorbyl Phosphate (85.4 %) in water at a dose of 5000 mg/kg bw and observed for 14 days.
Oral LD50:
Males > 5000 mg/kg bw
Females > 5000 mg/kg bw
Combined > 5000 mg/kg bw
No mortality occurred in this limit test. Sodium Ascorbyl Phosphate is of low Toxicity based on the LD50 in male and female rats. Weak and only transient clinical signs observed were: Impaired general state, Poor general state, Dyspnoea, Apathy, Staggering, Piloerection , Diarrhea. There were no treatment related necropsy findings or changes in body weight.
Dermal route:
In an acute dermal toxicity study (BASF AG, 1998), one group of young adult Wistar rats (5 /sex) were dermally exposed to Sodium ascorbyl phosphate (85.4 % in water) for 24 hours to at least 10 % of body surface are at a limit dose of 2000 mg/kg bw. Animals then were observed for 14 days.
Dermal LD50:
Males > 2000 mg/kg bw
Females > 2000 mg/kg bw
Combined > 2000 mg/kg bw
No mortality occurred in this limit test. Sodium ascorbyl phosphate is of low toxicity based on male and female animals. Only very slight erythema was observed on day 1 in some animals. There were no treatment related clinical signs, necropsy findings or changes in body weight.
Justification for classification or non-classification
Based on the results for oral and dermal acute toxicity (no mortality at limit doses, only weak clinical signs) Sodium ascorbyl phosphate is not classified according to EU Directive 67/548/EC amended and repealed by EU Regulation No.1272/2008 and CLP.
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