Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
No information
Author:
Anonymous
Year:
2010
Bibliographic source:
Category approach for PI, PAM and their salts, 2010

Materials and methods

Test guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 4h
Score:
1.28
Max. score:
8
Reversibility:
fully reversible within: 8d
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 4h
Score:
0.11
Max. score:
8
Reversibility:
fully reversible within: 8d
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 4h
Score:
1.29
Max. score:
8
Reversibility:
fully reversible within: 8d

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Classification : not irritating