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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study with acceptable restrictions.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Alcohols, C12-13, ethoxylated, sulfates, sodium salts
EC Number:
500-298-7
EC Name:
Alcohols, C12-13, ethoxylated, sulfates, sodium salts
Cas Number:
110392-50-2
IUPAC Name:
110392-50-2
Details on test material:
- Name of test material (as cited in study report): Lauryl ether sulphate
- Ethoxylation degree: 2
- Physical state: Pale yellow paste
- Analytical purity: 70%
- Lot/batch No.: No data

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
According to Guideline.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
2000, 3200, 4000, 5000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LD50
Effect level:
3 900 mg/kg bw
Sex:
male/female
Dose descriptor:
LD50
Effect level:
2 730 mg/kg bw
Based on:
act. ingr.
Mortality:
There were deaths among animals dosed at 4000 and 5000 mg/kg bw.
Clinical signs:
Signs of reaction to treatment observed in all rats shortly after dosing were pilo-erection, abnormal body carriage (hunched posture), abnormal gait (waddling), lethargy and diarrhoea. These were accompanied by:
- decreased respiratory rate in all rats dosed at 3.2 g/kg and above,
- ptosis in all rats dosed at 4.0 or 5.0 g/kg,
- pallor of the extremities in all rats dosed at 5.0 g/kg.
Body weight:
No effects.
Gross pathology:
No effects.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU