Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented study report, which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1970
Report Date:
1970

Materials and methods

Principles of method if other than guideline:
BASF test
GLP compliance:
no
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Ditridecylamin techn., Isomerengemisch
- Physical state: liquid

Test animals

Species:
mouse
Strain:
other: Kisslegg
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 0.1 - 30% emulsion with traganth
Doses:
12.5, 16, 20, 25, 100, 200, 1600 mm³/kg
No. of animals per sex per dose:
5
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, histopathology

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 10 mg/kg bw
Remarks on result:
other: Original data: 13 mm³/kg
Mortality:
All animals died at the concentrations of 16 mm³/kg and higher (equivalent to a concentration of ca. 12.3 mg/kg). At 12.5 mm³/kg (equivalent to a concentration of ca. 9.6 mg/kg) none of the males died compared to 3 of the females.
Clinical signs:
Dyspnea, staggering, atony, apathy and slight twitching
Gross pathology:
Sporadically, adhesions in the upper abdomen

Applicant's summary and conclusion