Registration Dossier
Registration Dossier
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EC number: 201-928-0 | CAS number: 89-65-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate,Erythorbic Acid, and sodium Erythorbate
- Author:
- F. Alan Andersen
- Year:
- 1 999
- Bibliographic source:
- International Journal of Toxicology
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Litton Bionetics, Inc performed activation and non-activation suspernsion tests using homogenates of liver, lungs, and testes and suspensions from adult male ICR mice, Sprague-Dawley rats, and Macca mulatta primates. The indicator organisms were S. typhimurium strains TA-1535, TA-1537, and TA-1538, and Saccharomyces cerevisiae strain D4.
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,3-didehydro-D-erythro-hexono-1,4-lactone
- EC Number:
- 201-928-0
- EC Name:
- 2,3-didehydro-D-erythro-hexono-1,4-lactone
- Cas Number:
- 89-65-6
- Molecular formula:
- C6H8O6
- IUPAC Name:
- (5R)-5-[(1R)-1,2-dihydroxyethyl]-3,4-dihydroxy-2,5-dihydrofuran-2-one
- Test material form:
- solid: crystalline
Constituent 1
Results and discussion
Test results
- Species / strain:
- other: TA-1535,TA-1537,TA-1538 and Scccharomyces cerevisiae strain D4
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Remarks:
- Not mentioned in the review article
- Remarks on result:
- other: other: homogenates of liver, lungs, and testes and suspensions from adult ICR mice, Sprague Dawley rats and Macaca mulatta primates.
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
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