Registration Dossier
Registration Dossier
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EC number: 201-928-0 | CAS number: 89-65-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Final Report on the Safety Assessment of Ascorbyl Palmitate, Ascorbyl Dipalmitate, Ascorbyl Stearate,Erythorbic Acid, and sodium Erythorbate
- Author:
- F. Alan Andersen
- Year:
- 1 999
- Bibliographic source:
- International Journal of Toxicology
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Maurer optimisation test
- GLP compliance:
- not specified
- Type of study:
- Maurer optimisation test
Test material
- Reference substance name:
- Ascorbic acid
- EC Number:
- 200-066-2
- EC Name:
- Ascorbic acid
- Cas Number:
- 50-81-7
- IUPAC Name:
- 5-(1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one (non-preferred name)
- Test material form:
- solid: crystalline
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Sex:
- female
Results and discussion
Any other information on results incl. tables
In a Maurer optimization test on female guinea pigs, after intradermal injection with and without Freund's Complete Adjuvant, no evidence was observed of sensitization by intradermal injection of 0.1ml of a 0.1% physiological saline, or by occluded epicutaneous application of 0.05ml/cm2 of 1 10% dispersion in petroleum ether.
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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