Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
review article or handbook
Title:
SIAM2 for substance L-Ascorbic acid
Author:
Melissa Thomas
Year:
1994
Bibliographic source:
SIDS Initial Assessment Report

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Reference substance name:
Ascorbic acid
EC Number:
200-066-2
EC Name:
Ascorbic acid
Cas Number:
50-81-7
IUPAC Name:
5-(1,2-dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one (non-preferred name)
Test material form:
solid: crystalline

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Amount / concentration applied:
>99%

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 72h
Score:
0.33

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information