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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1953
Report date:
1953
Reference Type:
study report
Title:
Unnamed
Year:
1951
Report date:
1951
Reference Type:
review article or handbook
Title:
High-Performance Fibers to Imidazole and Derivatives
Author:
Elvers B, Hawkins S, Ravenscroft M, Schulz G
Year:
1989
Bibliographic source:
Ullmann's Encyclopedia of Industrial Chemistry, 5th Edition, Vol A13, 1989

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
prior to OECD test guideline
Principles of method if other than guideline:
BASF-Test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401.
Test groups consisting of 5 animals/dose were treated by single gavage application with an aqueous solution of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy; animals that died during the observations period also were subjected to necropsy.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-vinylimidazole
EC Number:
214-012-0
EC Name:
1-vinylimidazole
Cas Number:
1072-63-5
Molecular formula:
C5H6N2
IUPAC Name:
1-ethenyl-1H-imidazole
Details on test material:
- Name of test material (as cited in study report): N-Vinylimidazol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:



ENVIRONMENTAL CONDITIONS
no data

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
VEHICLE
- Concentration in vehicle: 10% solution
Doses:
0.5, 1.0 and 2.0 cm3/kg (ca. 520, 1040 and 2080 mg/kg bw)
No. of animals per sex per dose:
5 animals per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 5 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: body weight

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 040 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Original data: 1 cm³/kg
Mortality:
520 mg/kg bw: no animals died
1040 mg/kg bw: 2/5 animals died
2080 mg/kg bw: all animals died within 2-5 days
Clinical signs:
other: No unusual findings were recorded

Applicant's summary and conclusion