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Diss Factsheets

Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

The substance is poorly biodegradable and has to be regarded as persistent in the environment.

Key value for chemical safety assessment

Biodegradation in water:
under test conditions no biodegradation observed

Additional information

Parent compound:

As key study regarding biodegradation a GLP test according to OECD 301B was identified (BASF 2012). The test uses non-adapted domestic activated sludge as inoculum and was prolonged to a test duration of 60 days. After this incubation period the CO2 removal was estimated to be <10% indicating that no biodegradation occurred.

This result is supported by an inherent biodegradability study according to OECD 302B where a TOC removal of < 20 % was measured (BASF AG 1979). Additionally, a QSAR estimation of the biodegradation according to EOCD 301C indicated 22% degrdation within 28days.


The model Catalogic 301 C v11.15 (OASIS Catalogic v5.13.1.156) calculated 40 metabolites (see document "1072 -63 -5_Metabolites_Catalogic 301C" attached under "attached background material") identifying 11 metabolites as relevant degradation products with an estimated quantity of≥ 0.1%.

Four out of eleven metabolites identified as relevant degradation products were calculated to be not readily biodegradable. Individual biodegradation of these metabolites was estimated to be between 10% and 48% after 28 days (based on BOD).

Due to these results the substance is considered persistent in the environment. Therefore, further testing on biodegradation is not deemed necessary as it won't reveal any relevant information for the assessment of the substance.