Registration Dossier
Registration Dossier
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EC number: 214-029-3 | CAS number: 1073-69-4
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Sensitization of guinea-pig skin to phenylhydrazine
- Author:
- Jadassohn
- Year:
- 1 930
- Bibliographic source:
- Klinische Wochenschrift, 9:551; cited in WHO 2000, Phenylhydrazine. CICAD 19, Wissenschaftliche Verlagsgesellschaft mbH
- Reference Type:
- secondary source
- Title:
- Concise International Assessment Document 19: Phenylhydrazine
- Author:
- WHO
- Year:
- 2 000
- Bibliographic source:
- Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart, ISBN 92 4 153019 7; ISSN 1020-6167
Materials and methods
- Principles of method if other than guideline:
- The skin of guinea pigs were painted with phenylhydrazine. After 2 - 3 weeks the not pretreated skin was painted with a 10 % alcoholic solution of phenylhydrazine.
- GLP compliance:
- no
- Type of study:
- skin painting test
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
- Details on test material:
- - Name of test material (as cited in study report): "Phenylhydrazin", phenylhydrazine
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- no data
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: alcohol
- Concentration / amount:
- 10 %
Challengeopen allclose all
- Route:
- epicutaneous, open
- Vehicle:
- other: alcohol
- Concentration / amount:
- 10 %
- No. of animals per dose:
- no data
- Details on study design:
- RANGE FINDING TESTS: no data
MAIN STUDY
A. INDUCTION EXPOSURE
- two to three weeks before the challenge exposure, the skin was treated with undiluted phenylhydrazine.
B. CHALLENGE EXPOSURE
- 10 % solution phenylhydrazine in alcohol was painted on an area other than the pretreated skin site. - Challenge controls:
- no data
- Positive control substance(s):
- no
Results and discussion
- Positive control results:
- no data
Any other information on results incl. tables
Applicant's summary and conclusion
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