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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
other: data from peer-reviewed handbook
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2004

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
Data from peer reviewed handbook. No information provided on methods.
GLP compliance:
no
Remarks:
reference dated 6-14-63.
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dicyclohexylcarbodiimide
EC Number:
208-704-1
EC Name:
Dicyclohexylcarbodiimide
Cas Number:
538-75-0
Molecular formula:
C13H22N2
IUPAC Name:
N,N'-dicyclohexylcarbodiimide

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
corn oil
Remarks:
undiluted, 10% or 1% in corn oil.
Doses:
2.5 - 3200 mg/kg
No. of animals per sex per dose:
31 rats.
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: up to 5 days.
- Other examinations performed: clinical signs, body weight.

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
10 mg/kg bw
Based on:
not specified
Mortality:
Deaths reported at 1/2 h - 3 days.
Clinical signs:
Slight to moderate weakness; after 24h, abdominal distension, tremor, not eating, labored respiration, cyanosis.

Applicant's summary and conclusion

Conclusions:
The acute intraperitoneal LD50 in rats was 10 mg/kg.
Executive summary:

According to 'Sax’s Dangerous Properties of Industrial Materials. 11th ed. (2004)' (peer reviewed handbook data), the test item has an acute intraperitoneal LC50 of 10 mg/kg in rats.