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Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
1. SOFTWARE : EPI-SUITE EPA (USA)

2. MODEL: ECOSAR v1.11

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
CAS Number: 538-75-0
SMILES: N(=C=NC(CCCC1)C1)C(CCCC2)C2

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL: The QMRF is available in "Attached justification".

5. APPLICABILITY DOMAIN : The QPRF is available in 'Attached justification'.

6. ADEQUACY OF THE RESULT : The QPRF is available in 'Attached justification'.
Guideline:
other: REACH Guidance on QSARs R.6
GLP compliance:
no
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
0.032 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
growth rate
Remarks on result:
other: calculated value.

ECOSAR v1.11 predicted that the substance has a 96h-EC50 = 0.032 mg/L in green algae.

Validity criteria fulfilled:
not applicable
Conclusions:
The calculated 96h-EC50 of the test item in algae is 0.032 mg/L.
Executive summary:

ECOSAR v1.11 calculation of the 96h-EC50 in algae was used. According to this method, the substance has a 96h-EC50 = 0.032 mg/L in green algae.

Description of key information

Key study: Method according to OECD 201, GLP study. The 72h-ELr50 of the test item in green algae was found to be 6.84 mg/L (95% CL: 6.27 - 7.42) and the NOELR was 3.1 mg/L (nominal concentrations, based on growth rate).

Supporting study: ECOSAR v1.11, accepted calculation method. The substance has a predicted 96h-EC50 = 0.032 mg/L in green algae.

Key value for chemical safety assessment

EC50 for freshwater algae:
6.84 mg/L
EC10 or NOEC for freshwater algae:
3.1 mg/L

Additional information