Registration Dossier
Registration Dossier
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EC number: 292-642-5 | CAS number: 90669-48-0
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
Log Pow > 9.4 (hydrocarbon waxes (petroleum), oxidised) , OECD 117, EU Method A.8, Fox (2012)
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 9.4
Additional information
In accordance with Column 2 of Annex VII Section 7.8 and Section 2 of Annex XI of Regulation (EC) No 1907/2006 the test cannot be performed on the registered substance as the substance does not dissolve in water or in octanol. Testing on the registered substance is therefore omitted.
Supporting information is available in the form of a report on a discontinued study. The aim of the study was to determine the partition coefficient of the registered substance, under GLP conditions and following the methods outlined in the standardised guidelines OECD 117 and EU Method A.8, using the HPLC method. However, the registered substance was found to be insufficiently soluble in different mobile phases recommended by the test guidelines to yield detectable signals in HPLC (UV and RI). Dilution of stock solutions in mobile phases resulted in precipitation of the test material. Testing was therefore discontinued.
In order to include quantitative information on octanol-water partitioning, information on the read across substance, hydrocarbon waxes (petroleum), oxidised, has been included for risk assessment purposes. Read across from this substance is justified on the basis of its similar physical and chemical properties to those of the registered substance. Furthermore, it has a very similar chemical structure; the registered substance is an esterified form of the read across substance.
In a GLP compliant partition coefficient study conducted in accordance with standardised guidelines OECD 117 and EU Method A.8, the n-octanol/water partition coefficient of the read across substance, hydrocarbon waxes (petroleum), oxidised, was determined using the HPLC method. Under the conditions of the study, the Log Pow of the test material was determined to be > 9.4. Since the study was conducted with the read across substance it was assigned a reliability score of 2 in line with the criteria of Klimisch (1997).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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