Registration Dossier
Registration Dossier
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EC number: 309-713-4 | CAS number: 100684-40-0 A complex combination of hydrocarbons obtained as a residue from the distillation of crude oil under vacuum. It consists predominantly of hydrocarbons having carbon numbers predominantly in the range above C50 and boiling in the range above approximately 500°C (932°F).
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Worker
| Effect | Route | DNEL | Dose Descriptor | Modified Dose Descriptor and Assessment Factors | |
| Acute Exposure | Systemic | Dermal | (a) | ||
| Inhalation | (a) | ||||
| Local | Dermal | (a) | |||
| Inhalation | (a) | ||||
| Long-Term Exposure | Systemic | Dermal | (a) | ||
| Inhalation | (a) | ||||
| Local | Dermal | (b) | |||
| Inhalation | 2.9 mg/m3/8h [corrected THC] | 17.2 mg/m3/day (predicted NOAEC based on mild upper respiratory tract irritation) | Dose descriptor was modified to correct starting point of 8.64 mg/m3/8h by adjustment for duration of exposure and level of activity. Then AF of 3 was applied for intraspecies and remaining differences. |
a) No hazard identified for this route (data available)
b) No-threshold effect and/or no dose-response information available
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
General Population
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic
|
Dermal |
(a) |
|
|
Inhalation |
(a) |
|
|
||
Oral |
(a) |
|
|
||
Local |
Dermal |
(a) |
|
|
|
Inhalation |
(a) |
|
|
||
Long-Term Exposure |
Systemic |
Dermal |
(a) |
|
|
Inhalation |
(a) |
|
|
||
Oral |
(a) |
|
|
||
Local |
Dermal |
(b) |
|
|
|
Inhalation |
0.6 mg/m3/24h |
17.2 mg/m3/day (predicted NOAEC based on mild upper respiratory tract irritation) |
Dose descriptor was modified to correct starting point of 3.1 mg/m3/24h by adjustment for duration of exposure. Then AF of 5 was applied for intraspecies and remaining differences |
a) No hazard identified for this route (data available)
b) No-threshold effect and/or no dose-response information available
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