Registration Dossier
Registration Dossier
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EC number: 240-183-6 | CAS number: 16040-69-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to fish
Key value for chemical safety assessment
Additional information
To assess the toxicity of CAS 16040 -69 -0 to fish, read across was performed to structural analogue substances.
Several studies on the similar substance CAS147-14-8 detected no lethal effects. All tests were run without analytical monitoring. A screening study performed in a static system with Brachydanio rerio according to OECD 203 determined a LC50 >100 mg/l at test termination after 96 h in (BASF AG 2004). The result is supported by two further studies. A semi-static test accomplished in compliance with OECD 203 using solubiliser detected a LC50 (96h) > 100 mg/l in Cyprinus carpio (Colour-Chem Ltd. 2001). Furthermore Oryzias latipes was exposed to the substance in a study following Japanese guideline JIS K 0102-1986-71. After 48 hours of exposure a LC50 >100 mg/l was determined (MITI 1992).
Comparable results were obtained by a test accomplished in compliance with German standard DIN 38412 part L15 using a solubiliser. The study was performed using static test system with Leuciscus idus as test organism. The test was terminated after 96 hours and a LC50 >2200 mg/l was determined (BASF AG 1978). In a second static test following German standard DIN 38412 part L15 without solubiliser a LC50 (96 h) of 3200 mg/l was determined (1978). A third test performed in compliance with German standard DIN 38412 part L15 determined a LC50 of ca. 46 mg/l in Leuciscus idus (BASF AG 1991). However, the test substance contained water soluble impurities that probably caused the toxic effects.
Acute toxicity tests performed with a second analogue substance of the category (CAS1328-53-6) obtained similar results. Two static studies in compliance with guideline EPA-660/3-75-009 (1975) on the toxicity of CAS 1328-53-6 on fish detected a LC50 (96h) of 355.6 mg/l in Oncorhynchus mykiss and of 752.4 mg/l in Lepomis macrochirus respectively (Union Carbide Corporation 1978). In a semi-static test set up with Cyprinus carpio following OECD guideline 203 a LC50 (96h) > 100 mg/l was determined (Colour-Chem limited 2000). A comparable result was obtained by a study with Oryzias latipes as test organism. The study run for 48 hours and a LC50 >250 mg/l was determined (MITI 1992).
Furthermore no toxicity in the range of water solubility was determined for the structural analogue substances CAS14302-13-7and CAS27614-71-7. Two OECD guideline 203 test on the respective substances detected a LC50 >100 mg/l after 96 hours.
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