Registration Dossier
Registration Dossier
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EC number: 201-622-7 | CAS number: 85-68-7
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
72 hr EC50 values for Scenedesmus subspicatus and Naviculla pelliculosa exposed to benzyl butyl phthalate were available. The most sensitive was a test on Scenedesmus subspicatus: 0.325 mg/L. The most sensitive NOEC, also for Scenedesmus subspicatus, was 0.15 mg/L.
Key value for chemical safety assessment
Additional information
Four studies were reviewed for this endpoint and were considered key studies for this endpoint . These were GLP compliant studies following standard guidelines and are useable as key studies for the fulfilment of this endpoint. These four concern static, 72 h tests.
Huntingdon Life Sciences (2000a) reports an EC50 for Scenesmus subspicatus of 1.5 mg/L - this relates to growth rate. The NOEC was 0.15 mg/L. This test followed the OECD 201 and EU Method C3 guidelines.
Huntingdon Life Sciences (2000b) reports an EC50 for Naviculla pelliculosa of 0.66 mg/L - this relates to biomass which is the most sensitive endpoint. The NOEC was 0.17 mg/L. This test followed the OECD 201 and EU Method C3 guidelines.
Carolina Ecotox (1995a) reports an EC50 for Naviculla pelliculosa of 0.414 mg/L - this relates to area under the growth curve. This test followed the OECD 201 and EC Annex V - Supplement guidelines.
Carolina Ecotox (1995b) reports an EC50 for Scenedesmus subspicatus of 0.325 mg/L - this relates to area under the growth curve. This test followed the OECD 201 and EC Annex V - Supplement guidelines.
NOECs were not taken from the Carolina Ecotox studies as they related to cell counts.
Supporting studies from Monsanto (1985) and ABC Laboratories (1996) report EC50 values of 0.52 and 0.31 mg/L respectively.
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