Registration Dossier
Registration Dossier
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EC number: 605-717-8 | CAS number: 174333-80-3
Specific investigations: other studies
Administrative data
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to P. Sohoni and J.P. Sumpter (1998)
- Principles of method if other than guideline:
- The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Androgenic as well as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
- GLP compliance:
- no
- Type of method:
- in vitro
Test material
- Reference substance name:
- 2-[(hydroxyimino)methyl]-4-(2-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(3-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(4-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(nonan-2-yl)phenol
- EC Number:
- 605-717-8
- Cas Number:
- 174333-80-3
- Molecular formula:
- C16H25NO2
- IUPAC Name:
- 2-[(hydroxyimino)methyl]-4-(2-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(3-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(4-methyloctyl)phenol; 2-[(hydroxyimino)methyl]-4-(nonan-2-yl)phenol
- Details on test material:
- - Name of test material: C9Aldoxim
- Physical state: Liquid, greenyellow, clear
- Analytical purity: >90%
- Storage condition of test material: Room temperature
Constituent 1
Test animals
- Species:
- other: yeast
Administration / exposure
- Vehicle:
- DMSO
Results and discussion
- Details on results:
- In this study, the test substance C9 Aldoxim showed no androgenic activity in comparison to dihydrotestosterone.
In this study, the test substance C9 Aldoxim showed clear antiandrogenic activity from about 10-6 mol/L onward in comparison to hydroxyflutamide.
No cytotoxicity was observed.
Applicant's summary and conclusion
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