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EC number: 605-717-8 | CAS number: 174333-80-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Auto flammability
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- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
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- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
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- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
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- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- no analytics
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Lix 860 N (neat reagent); Nonylsalicylaldoxime
- Physical state: fluid
- Analytical purity: >99%
- Lot/batch No.: 070596
- Purity test date: September 1994
- Expiration date of the lot/batch: September 1997 - Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: The test substance was directly added to the test vessel and homogenized for 10 seconds.
- Evidence of undissolved material (e.g. precipitate, surface film, etc): The test concentrations og 8 mg/L was slightly turbid. - Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: zebra fish
- Source: Charles River Aquatics
- Feeding during test: no
ACCLIMATION
- Acclimation period: 7 days
- Acclimation conditions (same as test or not): same as test
- Type and amount of food: SSNIFF M
- Health during acclimation (any mortality observed): < 5% mortality - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Test temperature:
- 20.5 - 21.7 °C
- pH:
- 7.7 - 8.4
- Dissolved oxygen:
- >= 70% saturation
- Nominal and measured concentrations:
- Nominal: 1, 2, 4 and 8 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 10 L aquaria with 5 L test solution
- Renewal rate of test solution (frequency/flow rate): every 24 h
- No. of organisms per vessel: according to guideline
- No. of vessels per concentration (replicates): according to guideline
- No. of vessels per control (replicates): according to guideline
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
OTHER TEST CONDITIONS
- Photoperiod: 16h light: 8h dark
EFFECT PARAMETERS MEASURED: mortality was recorded after 2-4, 24, 48, 72 and 96h test duration. - Reference substance (positive control):
- no
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: after 48 hours one fsih showed distrubed equilibrium
- Mortality of control: none
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: for the highest concentration a slight turbidity was observed at all observation times - Validity criteria fulfilled:
- yes
- Conclusions:
- In a GLP study according to the EU Method C.1, the LC50 for acute toxicity to fish of the test substance was determined to be 1.1 mg /l.
- Executive summary:
The acute toxicity of the test substance to fish was evaluated in a study according to EU Method C.1 under GLP conditions. In a semi-static study Brachydanio rerio was exposed for 96h. The test material was applied directly to the test vessels. Analytical monitoring in water was omited due to the very low water solubility. All validity criteria were fulfilled. The LC50 is determined to be 1.1 mg/L (nominal concentration based on loadings).
Reference
Description of key information
LC50 (96h) = 1.1 mg/L (nominal) for Danio rerio (EU method C.1)
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.1 mg/L
Additional information
One study investigating the short-term toxicity of the test substance to freshwater fish is available. The study was performed according to GLP and EU method C.1 using Danio rerio as test organism (Scholz 1996). The test material was applied directly to the test vessels. Analytical monitoring in water was omited due to the very low water solubility. All validity criteria were fulfilled. The LC50 is determined to be 1.1 mg/L based on nominal concentration.
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