Registration Dossier
Registration Dossier
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EC number: 222-323-8 | CAS number: 3425-89-6
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation
- Remarks:
- other: based on human data
- Type of information:
- other: Review
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: MAK review
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- List of MAK and BAT values 2000, Maximum concentrations and Biological Tolerance Values at the Workplace
- Author:
- Commission for the investigation of health hazards of chemical compounds in the work area
- Year:
- 2 000
- Bibliographic source:
- published by Willey-Vch, Deutsche Forschungsgemeinschaft
- Reference Type:
- review article or handbook
- Title:
- Guide to occupational exposure values 2002
- Author:
- ACGIH
- Year:
- 2 002
- Bibliographic source:
- ed by ACGIH ISBN: 1-882417-47-X
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- no
Test material
- Reference substance name:
- Tetrahydromethylphthalic anhydride
- EC Number:
- 234-290-7
- EC Name:
- Tetrahydromethylphthalic anhydride
- Cas Number:
- 11070-44-3
- IUPAC Name:
- 3a-methyl-3a,4,5,6-tetrahydro-2-benzofuran-1,3-dione
- Reference substance name:
- Methyltetrahydrophthalic anhydride
- IUPAC Name:
- Methyltetrahydrophthalic anhydride
- Details on test material:
- no details given
Constituent 1
Constituent 2
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no details given
Test system
- Route of induction exposure:
- inhalation
- Route of challenge exposure:
- inhalation
- Vehicle:
- not specified
- Concentration:
- no details given
- No. of animals per dose:
- no details given
- Details on study design:
- no details given
- Challenge controls:
- no details given
Results and discussion
- Results:
- MTHPA was classified as "Sa", danger of sensitization of airways by the German MAK commission (Commission for the investigation of health hazards of chemical compounds in the work area).
Substances classified as "Sa" can cause symptoms of the airways and also of the conjunctiva (substances causing airway sensitization). - Positive control results:
- no details given
- Negative control results:
- no details given
Any other information on results incl. tables
no details given
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Conclusions:
- Tetrahydromethylphthalic anhydride (MTHPA) classified as sensitising to the respiratory tract.
- Executive summary:
- Tetrahydromethylphthalic anhydride (MTHPA) was classified as "Sa", danger of sensitization of airways by the German MAK commission (Commission for the investigation of health hazards of chemical compounds in the work area). Substances classified as "Sa" can cause symptoms of the airways and also of the conjunctiva (substances causing airway sensitization).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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