2-methoxyethyl 2-cyanoacrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Comparable to guideline study with acceptable restrictions (no GLP)

Justification for type of information:

Ethyl 2-cyanoacrylate (ECA) is a structural homologue that contains additional CH2-group (see attached justification).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Ethyl 2-cyanoacrylate

EC Number:

230-391-5

EC Name:

Ethyl 2-cyanoacrylate

Cas Number:

7085-85-0

Molecular formula:

C6H7NO2

IUPAC Name:

ethyl 2-cyanoacrylate

Test material form:

liquid

Details on test material:

- Name of test material: Depend, IS 04E
- Description of test material: transparent, viscous liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: the body weight ranged from 206 to 246 g
- Fasting period before study: 18 hours

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

No. of animals per sex per dose:

6 male albino rats

Control animals:

no

Details on study design:

The test compound was administered by oral intubation to 1 group of 6 male albino rats fasted for 18 hours prior to dosing. The animals were observed during the day of dosing and daily thereafter for 14 days. Decents during the study were examined for gross lession.

Results and discussion

Effect levels

Key result

Sex:

male

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

One rat died on the fourth day.

Gross pathology:

Hemorrhagic lungs. Solid mass in stomach, not adhered to stomach wall but too large to pass through pyloric valve. Cardic portion of stomach distended. Food in intestines as in a normal rat. One rat had dilated intestinal blood vessels.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The oral LD50 of ethyl-2-cyanoacrylate is estimated to be higher than 5000 mg/kg body weight in rats for a single dose. Therefore the test substance ethyl-2-cyanoacrylate is practically nontoxic according to the EC-guideline 93/21.
Therefore, the test substance ethyl-2-cyanoacrylate can be considered as practically nontoxic. Based on structural analogy and a comparable reaction mechanism (polymerization in contact with moisture), it is concluded that the acute toxicity potential of 2-methoxyethyl 2-cyanoacrylate will also be low.