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Diss Factsheets

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

long-term toxicity to aquatic invertebrates
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other justification
Justification for data waiving:

Description of key information

not toxic at the limit of water solutbility.

Key value for chemical safety assessment

Additional information

The endpoint was covered by read across from tin sulfide.

The 21-day-chronic toxicity of Tin sulfide to Daphnia magna was studied under semistatic conditions. Daphnids were exposed to 5 concentrations prepared through dilution of a saturated solution from nominal 20 mg/L prepared in Elendt M7 medium. The measured value in the highest concentration was 11.3 µg/L.  The 21 day NOEC based on reproduction was 3 µg/L (equals to 12.5 % of maximum soluble fraction of 20 mg/L. EC50 values are higher than the solubility limit of the test item under test conditions.

The sublethal effects included were reproduction output, reduction of parent growth and intrinsic rate. The most sensitive end point was reduction of reproduction output.


This study is considered as valid and satisfies the guideline requirements for a chronic toxicity study with freshwater invertebrates.

Conclusion: Effects from tin sulfide were only observed at concentrations higher than the water solubility of tin sulfide (0.6 µg/L). Therefore, these effects are considered as not relevant. Read across from tin sulfide to tin disulfide was considered as possible (see Read Across justification document attached to the dossier). Hence it can be concluded that there is no long-term toxicity to invertebrates at the limit of water solubility of tin disulfide, i.e., at 0.67 µg/L.