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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
Reference
Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Guideline:
other: Shelanski RIPT
GLP compliance:
not specified
Type of study:
other: human patch test
Species:
human
Vehicle:
other: butyl carbitol
Concentration / amount:
1%
Vehicle:
other: butyl carbitol
Concentration / amount:
1%
No. of animals per dose:
100
Vehicle:
acetone/olive oil (4:1 v/v)
Concentration:
25 microliter 0% (vehicle control), 1%, 10%, 25%, 50%
No. of animals per dose:
5
Positive control substance(s):
hexyl cinnamic aldehyde (CAS No 101-86-0)
Reading:
other: no data
Group:
test chemical
Dose level:
1% in butyl carbitol
No. with + reactions:
0
Total no. in group:
100
Remarks on result:
other: Reading: other: no data. Group: test group. Dose level: 1% in butyl carbitol. No with. + reactions: 0.0. Total no. in groups: 100.0.
Interpretation of results:
not sensitising
Remarks:
Migrated information Criteria used for interpretation of results: EU
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

The substance was found not to be a sensitizer in a cohort of 100 humans