Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 618-804-0 | CAS number: 919-94-8
Carcinogenicity
Administrative data
Description of key information
In accordance with column 2 of REACH Annex X, as TAEE is not considered mutagenic and as there is no evidence regarding hyperplasia induction and/or pre-neoplastic lesions from the subchronic repeated dose studies with the structure analogues TAME (2-methoxy-2-methylbutane) and ETBE (2-ethoxy-2-methylpropane), a carcinogenicity study is not needed for TAEE.
Key value for chemical safety assessment
Justification for classification or non-classification
Based on the negative results of the available in vitro genotoxicity studies with TAEE and the absence of evidence regarding hyperplasia induction and/or pre-neoplastic lesions from the subchronic repeated dose studies with the structure analogues TAME and ETBE, classification is not necessary for carcinogenicity in accordance with Directive 67/548/EEC and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
