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EC number: 204-070-5 | CAS number: 115-19-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 966
- Report date:
- 1966
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 000
- Reference Type:
- secondary source
- Title:
- SIDS Initial Assessment Report - 2-Methylbut-3-yn-ol
- Author:
- BASF AG
- Year:
- 2 002
- Bibliographic source:
- OECD SIDS
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Principles of method if other than guideline:
- Internal BASF method was used, which was in large part equivalent to methods described in OECD Guideline 404
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methylbut-3-yn-2-ol
- EC Number:
- 204-070-5
- EC Name:
- 2-methylbut-3-yn-2-ol
- Cas Number:
- 115-19-5
- Molecular formula:
- C5H8O
- IUPAC Name:
- 2-methylbut-3-yn-2-ol
- Details on test material:
- - Analytical purity: 98.5%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.9, 2.78 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other side of same animal, treated with saline
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.2 ml
- Concentration (if solution): 100% - Duration of treatment / exposure:
- 1 min, 5 min, 15 min, 20 h
- Observation period:
- 5 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm of back skin
- Type of wrap if used: cotton pad (seize: 2.5 cm x 2.5 cm) saturated with the undiluted test substance (ca. 0.5 ml)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): 50% Lutrol (polyethylenglycol) dilution in water
- Time after start of exposure: 1, 5, 15 min and 20 h
SCORING SYSTEM:
Erythema and edema were scored according the below described system:
Although the results in the report were originally not given as Draize scores the data can be transferred into the Draize scoring system (in brackets). (+) = none - negligible effect (0)
+ = slight effect (1)
++ = moderate effect (2)
+++ = severe effect (>= 3)
N = necrosis
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: after 20 h application
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: after 20 h application
Any other information on results incl. tables
Irritation scores acc. Draize::
Readings | Animal | Exposure period: 1 min | Exposure period: 5 min | Exposure period: 15 min | Exposure period: 20 h | ||||||||
Erythema | Edema | Additional findings | Erythema | Edema | Additional findings | Erythema | Edema | Additional findings | Erythema | Edema | Additional findings | ||
1h | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||
24 h | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | overlapping test site | |||
2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||
48 h | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||
72 h | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||
96 h | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |||||
Mean 24 - 72 h | 1 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.7 | 0 | ||||
2 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | |||||
Mean | 0 | 0 | 0 | 0 | 0 | 0 | 0.3 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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