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EC number: 204-004-5 | CAS number: 112-76-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets scientific standards with acceptable restrictions (limited documentation, e.g. no details about test substance or applied amount of test substance)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- White Vienna rabbits were used. Usually, 2 animals were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions.
An application site of 2.5 X 2.5 cm was covered with the liquid or powdered and moistened test substance. In addition, skin tissue from the ear was
tested by wrapping the ear. These results from the ear, however, would not be taken into account for evaluation as they do not represent testing of the dorsal/lateral flank of the back. After the application time, the skin was washed with water which sometimes contained a mild detergent.
The animals were observed 7 to 8 days and skin changes were recorded on working days. Tests used occlusive dressing, in contrast to the semiocclusive dressing specified by the guidelines. - GLP compliance:
- no
Test material
- Reference substance name:
- stearic acid chloride
- IUPAC Name:
- stearic acid chloride
- Details on test material:
- - Name of test material (as cited in study report): Stearinsäurechlorid
- Physical state: liquid
- Analytical purity: 98 %
- pH: acidic
- melting point: 7,3
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no volume or weight reported. an application site of 2,5 x 2,5 cm was coverd with liquid - Duration of treatment / exposure:
- Experiment 1: 1, 5, or 15 minutes
Experiment 2: 20 h - Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: An aerea of 2,5 x 2.5 cm of the flank was exposed
- Type of wrap if used: occlusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done): After the exposure time, the skin was washed with 50% Lutrol in water.
- Time after start of exposure: 20 h
SCORING
- see table below
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Remarks:
- 20 h occlusive exposure
- Time point:
- other: 24 h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Remarks:
- occlusive exposure 20 h
- Time point:
- other: 24 h
- Score:
- ca. 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Remarks:
- 20 h occlusive exposure
- Time point:
- other: 24
- Score:
- ca. 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Remarks:
- 20 h occlusive exposure
- Time point:
- other: 24 h
- Score:
- ca. 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
Any other information on results incl. tables
Since irritation data are recommended for a 4 h skin exposition, results of the available 20 h and the 15 min exposition will serve as approximation.
Descriptive scores of the raw data have been converted to Draize numerical scores.Erythema scoring was at the border of the necrotic aerea.
Exposition: |
20 h |
|||
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
2 |
1 |
|
2 |
24 h |
2 |
0 |
necrosis |
1 |
48 h |
2 |
1 |
|
2 |
48 h |
2 |
0 |
necrosis |
1 |
72 h |
2 |
1 |
|
2 |
72 h |
1 |
0 |
necrosis |
1 |
8 d |
0 |
0 |
superficial necrosis squamation |
2 |
8 d |
0 |
0 |
necrosis squamation |
mean |
24 - 48 h |
2.0 |
0.5 |
|
|
|
|
|
|
Exposition: |
15 min |
|||
Animal |
Reading |
Erythema |
Edema |
Comment |
1 |
24 h |
2 |
1 |
|
2 |
24 h |
2 |
0 |
|
1 |
48 h |
2 |
1 |
|
2 |
48 h |
2 |
0 |
|
1 |
72 h |
2 |
1 |
|
2 |
72 h |
1 |
0 |
|
1 |
8 d |
0 |
0 |
squamation |
2 |
8 d |
0 |
0 |
squamation |
mean |
24 - 72 h |
2.5 |
3.25 |
|
Applicant's summary and conclusion
- Executive summary:
Study meets scientific standards with acceptable restrictions (limited documentation, e.g. no details about test substance or applied amount of test substance). 2 rabbits were treated for 1, 5 and 15 minutes and 2 other animals for 20 hours using occlusive conditions. An application site of 2.5 X 2.5 cm was covered with the liquid or powdered and moistened test substance. After the application time, the skin was washed with water which sometimes contained a mild detergent. The animals were observed 8 days and skin changes were recorded on working days. Marked erythema, slight edema and minimal necrotic effects were obseved afte 20 h occlusive exposure. Marked erythema, slight edema but not any necrotic effects were see after 15 min exposure.
Conclusion
The test substance was graded irritating. Minor necrotic effects after 20 h occlusive exposure were judge to be due to the more stringent test procedure in comparisson to a OECD Guideline study.
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