Stearoyl chloride

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981) with acceptable restrictions (partly limited documentation; post exposure observation period 7 days; low number of rats)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1970

Report date:

1970

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Version / remarks:

Annex of the Guideline

Deviations:

no

GLP compliance:

no

Test type:

other: Inhalation Hazard Test

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Stearic acid chloride

IUPAC Name:

Stearic acid chloride

Details on test material:

- Name of test material (as cited in study report): Stearinsäurechlorid
- Physical state: liquid
- Analytical purity: 98 %
- pH: acidic
- melting point: 7,3

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 534 g (group 1, mean male), 440 g (group 1, mean female), 490 g (group 2; mean male), 485 g (group 2; mean female)

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

Rats exposed for 8 h to a vapour saturated atmosphere at 20 °C. Vapour was generated by bubbling 200 l/h dry air (no CO2) through the liquid substance column (volume ca. 50 ml) of about 5 cm above a fritted glass disc in a glass cylinder.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

8 h

Concentrations:

vapour saturated atmosphere at 20 °C (vapor pressure < 1mbar at 20 °C)

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations and weighing: weighing at beginning and at temination of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LC0

Exp. duration:

8 h

Remarks on result:

other: saturated vapor

Mortality:

no mortality occurred

Clinical signs:

other: attempts to escape bloody discharge from eyes and nose

Body weight:

Mean body weight
group 1 male: 584 g (beginning), 679 g (termination)
group 1 female: 440 g (beginning), 534 g (termination)
group 2 male: 490 g (beginning), 607 g (termination)
group 2 female: 485 g (beginning), 594 g (termination)

Gross pathology:

nothing abnormal detected

Applicant's summary and conclusion

Executive summary:

Study is comparable with the inhalation hazard test described in the Annex of OECD Guideline 403 (adopted 1981).

6 rats per sex were exposed sequentially to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder. No death occurred when animals are exposed to a saturated atmosphere of stearoyl chloride for 8 h. The inhalation of a saturated atmosphere represents no acute hazard.

Conclusion

No death occurred when animals are exposed to a saturated atmosphere of stearoyl chloride for 8 h. The inhalation of a saturated atmosphere represents no acute hazard.