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EC number: 204-004-5 | CAS number: 112-76-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Adult laboratory rats were purchased from a breeder. Usually the source and strain of the animals were not documented. Several groups of 5 rats per sex and dose were treated simultaneously by gavage with preparations of the test substance in a suitable vehicle. The concentrations of these preparations were usually adjusted to achieve comparable volumes (e.g. 10 ml) per kg body weight.
Group-wise documentation of clinical signs was performed over the 14- day study period. Body weight was determined before the start of the study only, as it was needed for determination of dose. The clinical signs and findings were reported in summary form. More details e.g. on substance preparation, or dose and time dependence of symptoms, can be inferred from the German hand written raw data.
On the basis of the observed lethality, the LD50 value was determined by probit analysis. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- stearic acid chloride
- IUPAC Name:
- stearic acid chloride
- Details on test material:
- - Name of test material (as cited in study report): Stearinsäurechlorid
- Substance type: substance
- Physical state: liquid
- Analytical purity: 99 %
- Molecular weight: 302,5
- Desity: 0.95
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 100%, 76,6%, 43 %, 20 %, 9,3 %
- Justification for choice of vehicle: low toxicity, stability and soulubility of the test subsance
MAXIMUM DOSE VOLUME APPLIED:
1,56 ml
- Doses:
- 464, 1000, 2150, 3830, 5000, 6810, 8250 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Observations: <15 min; 15 min 30 min, 1 h, 2 h, 4 h, 5 h post administration on the day of administration , once daily thereafter except on weekends and holidays
Weighing: prior to administration, on day 7 and at termination of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- Probit analysis
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 783 mg/kg bw
- 95% CL:
- >= 5 047 - <= 6 570
- Mortality:
- no mortality occorred in doses up to 3830 mg/kg (details see table below)
- Clinical signs:
- other: Apathy, ataxia, tremor, irregular respiration, abdominal posture, poor general condition (details see table below)
- Gross pathology:
- 5000, 6810, 8250 mg/kg: stomach ulcer, bloody stomach, necrotic stomach mucosa, diarrhea
464, 1000, 2150, 3830 mg/kg: nothing abnormal detected
Any other information on results incl. tables
Dose [mg/kg] |
Mortality |
Clinical observation
|
Mean body weight [g] |
8250 |
5/5 male 5/5 female |
Apathy, ataxia, tremor, irregular respiration, abdominal posture, poor general condition |
Beginning: 180 g (male) ; 160 g (female) Day 7: - Day 14: - |
6810 |
3/5 male 3/5 female |
Apathy, ataxia, tremor, irregular respiration, poor general condition |
Beginning: 190 g (male) ; 160 g (female) Day 7: 210 g (male) ; 186 g (female) Day 14: 238 g (male) ; 203 g (female) |
5000 |
1/5 male 2/5 female |
Apathy, ataxia, irregular respiration, poor general condition |
Beginning: 230 g (male) ; 180 g (female) Day 7: 254 g (male) ; 205 g (female) Day 14: 260 g (male) ; 230 g (female) |
3830 |
0/5 male 0/5 female |
Nothing abnormal detected |
Beginning: 190 g (male) ; 160 g (female) Day 7: 255 g (male) ; 188 g (female) Day 14: 295 g (male) ; 199 g (female) |
2150 |
0/5 male 0/5 female |
Nothing abnormal detected |
Beginning: 200 g (male) ; 170 g (female) Day 7: 269 g (male) ; 211 g (female) Day 14: 301 g (male) ; 226 g (female) |
1000 |
0/5 male 0/5 female |
Nothing abnormal detected |
Beginning: 200 g (male) ; 170 g (female) Day 7: 247 g (male) ; 209 g (female) Day 14: 298 g (male) ; 219 g (female) |
464 |
0/5 male 0/5 female |
Nothing abnormal detected |
Beginning: 210 g (male) ; 170 g (female) Day 7: 275 g (male) ; 208 g (female) Day 14: 300 g (male) ; 219 g (female) |
Applicant's summary and conclusion
- Executive summary:
The study is comparable to OECD Guideline 401 with acceptable restrictions (partly limited documentation, e.g. only
mean bodyweight reported). Groups of 5 male and 5 female rats were gavaged at dose levels of 464, 1000, 2150, 3830, 5000, 6810 and 8250 g/kg bw. The post-exposure observation period was 14 days. Clinical signs like tremor, apathy, unsteady respiration were observed 1 h until day 1 after administration. No death occurred at concentrations up to 3850 mg/kg. The LD50 value is 5783 mg/kg. Therefore, the testsubstance is considerd to be relatively harmless after oral administration.
Conclusion
No death occurred at concentrations up to 3850 mg/kg. The LD50 value is > 5000 mg/kg. Therefore the test substance is considerd to be relatively harmless after oral administration.
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