Registration Dossier
Registration Dossier
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EC number: 202-870-9 | CAS number: 100-61-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Data originate from collection of data by the American Conference of Governmental Industrial Hygienists.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Documentation of the Threshold Limit Values and Biological Exposure Indices
- Author:
- Not specified
- Year:
- 1 991
- Bibliographic source:
- American Conference of Governmental Industrial Hygienists, 6th ed. Volumes I, II, III. Cincinnati, OH: ACGIH, p. 943
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The application of the substance on the intact skin of a rabbit for at least 1 hour.
- GLP compliance:
- not specified
- Test type:
- other: Exposure for 1 hour
Test material
- Reference substance name:
- N-methylaniline
- EC Number:
- 202-870-9
- EC Name:
- N-methylaniline
- Cas Number:
- 100-61-8
- Molecular formula:
- C7H9N
- IUPAC Name:
- N-methylaniline
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- At least 1 hour.
- Doses:
- Reported: at least 3 grams per kg bw.
- No. of animals per sex per dose:
- Not specified.
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD100
- Effect level:
- 3 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Application of 3 grams or more per kg of body weight upon the intact skin of a rabbit for 1 hour or more always produced death.
- Clinical signs:
- other: other:
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Based on these data it is not possible to give a reliable interpretation of the dermal toxicity of test substance. According to the CLP-regulation the highest value for classification is a LD50 of 2000 mg/kg bw.
- Conclusions:
- The test substance caused acute lethal poisoning by percutaneous absorption at applications of 3000 mg/kg body weight and higher.
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