Registration Dossier

Diss Factsheets

Toxicological information

Endpoint summary

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Short description of key information on bioaccumulation potential result:
test substance is essentially found in the liver, but also in the kidney, lung, small intestine, brain and bladder tissue. It yields to the formation of aniline, p-methylaminophenol and N,N-dimethylaniline depending on the species.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

Limited substance-specific data on the toxicokinetic behaviour of the test substance (CAS number 100-61-8) are available. The substance is readily absorbed by all three exposure routes (inhalation, dermal and oral) (SCOEL, 2010). Distribution in the body is reported to occur toliver, kidney, lung, small intestine, brain and bladder tissues (HSDB, 2009).The substance is metabolized in the liver by demethylation to aniline and/or hydroxylation of the aromatic ring to o- and p-methylaminophenols (SCOEL, 2010). The test substance has a low potential for bioaccumulation, as it is readily excreted in urine (SCOEL, 2010).