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EC number: 234-148-4 | CAS number: 10563-29-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP, OECD guideline n° 401 (1987 February 24th)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- N'-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine
- EC Number:
- 234-148-4
- EC Name:
- N'-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine
- Cas Number:
- 10563-29-8
- Molecular formula:
- C8H21N3
- IUPAC Name:
- {3-[(3-aminopropyl)amino]propyl}dimethylamine
- Details on test material:
- - Name of test material (as cited in study report): Dimethyldipropylenetriamine
- Physical state: Liquid
- Analytical purity: 99.49%
- Purity test date: 1991-01-22
- Lot/batch No.: P 90.11
- Expiration date: no data
- Storage condition of test material: stored at room temperature, kept away from light
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: ICO: OFA-SD (IOPS Caw) supplied by Iffa Crédo, 69210 L'Arbresle, France
- Age at study initiation: approximalety 6 weeks
- Weight at study initiation: males: 184+/-5g, females 152+/-7g
- Fasting period before study: 18 hours before administration
- Housing: 5 animals of the same sex per cage during study
- Diet (e.g. ad libitum): ad libitum pellet diet "Rats-Mice sustenance ref. A04 C" (U.A.R. 91360 Villemoisson-sur-Orge)
- Water (e.g. ad libitum): ad libitum tap water filtered by a 0,22µ filter membrane (Société Millipore, 78140 Vélizy, France)
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-3°C
- Humidity (%): 50+/-20%
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: 1991-04-23
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: volume taking into consideration that the specific gravity (SG) of the test substance was 0.88.
- Doses:
- 1000, 2000, 3000 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical signs checked once daily, animals weighted on day 5, 8 and 15
- Necropsy of survivors performed: yes, necropsy on all animals.
- Other examinations performed: Macroscopic examination on digestive track, heart, kidneys, libver, lungs, pancreas, spleen and any other organ with obvious anormalities. No histological examination was performed. - Statistics:
- LD50 calculated according to a Probit analysis, Finney's method published by E. Weber and Bliss' method.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 669 mg/kg bw
- 95% CL:
- 1 249 - 2 086
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 545 mg/kg bw
- 95% CL:
- 690 - 2 379
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 907 mg/kg bw
- 95% CL:
- 467 - 2 273
- Remarks on result:
- other: 90% CL (not 95 %)
- Mortality:
- 1000mg/kg: 10% (1 female found dead on day 7)
2000mg/kg: 60%
3000mg/kg: 100% - Clinical signs:
- other: 1000mg/kg: hypokinesia bewteen 15 minutes and 6 hours 2000mg/kg: sedation, hypokinesia, dyspnea between 15 minutes and 6 hours, accompanied by tremors in 2 animals after 4 hours and coma for 1 animal after 6 hours. Hypokinesia persited therafter in a few
- Gross pathology:
- 1000mg/kg: no apparent abnormalities observed
2000mg/kg: 1 female found dead on day 1, dark reddinsh stomach and intestines
2000mg/kg: 1 males found dead on day 1, dark stomach and black spleen
3000mg/kg: 2 males and 3 females on day 1, dark reddish stomach and intestineswith black liver and spleen.
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 of DIMETHYLDIPROPYLENETRIAMINE administered by oral route in rats was
- males, 1907 (467 - 2273) mg/kg with 90% confidence interval limits,
- females, 1545 (690 - 2379) mg/kg with 95% confidence interval limits,
- combined, 1669 (1249 - 2086) mg/kg with 95% confidence interval limits. - Executive summary:
The acute oral toxicity of Dimethyldipropylenetriamine was evaluated in rats according to OECD N°401 guideline. The test item was administered by oral route (gavage at 1000, 2000 and 3000 mg/kg) to groups of 10 Sprague-Dawley rats (5 males and 5 females). Animals were observed for 14 days.
100% mortality was observed for the high dose group on day 1 ; after administration animals showed sedation, lateral recumbency, piloerection and coma. These clinical signs were less severe in 2000 mg/kg group, althought 60% mortality was observed on day 5. The low dose group showed hypokinesia after treatment but only 10% mortality was observed. Under these experimental conditions, the oral LD50 of the test item is 1669 (1249 - 2086) mg/kg with 95% confidence interval limits.
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