Registration Dossier
Registration Dossier
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EC number: 237-487-6 | CAS number: 13814-97-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted by GLP accredited lab according to OECD method n. 401
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
Test material
- Reference substance name:
- Tin(II) bis(methanesulfonate)
- EC Number:
- 401-640-7
- EC Name:
- Tin(II) bis(methanesulfonate)
- IUPAC Name:
- tin(II) bis(methanesulfonate)
- Reference substance name:
- 53408-94-9
- EC Number:
- 610-996-4
- Cas Number:
- 53408-94-9
- IUPAC Name:
- 53408-94-9
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- No. of animals per sex per dose:
- 5
- Statistics:
- slope of log10(dose) = 11.3 for combined sexes with standard error deviation = 3.24
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 621 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 1 272 - < 2 087
Any other information on results incl. tables
In the dose ranging study all animals died at 5000 and 2500 mg/kg and one female at 1250 mg/kg died within 3 days of dosing.
Common abnormalities noted at necropsy were darkening and thickening of the stomach glandular mucosa and a pink colouration of the mucosa. There were several incidences of occular damage and discoloration of the undersurface of the lobes of the liver.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- harmful is swallowed
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