Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 270-670-9 | CAS number: 68476-29-9 A complex combination of light gases produced by distillation of crude oil and by catalytic reforming of naphtha. It consists of hydrogen and hydrocarbons having carbon numbers predominantly in the range of C1 through C4 and boiling in the range of approximately -217°C to -12°C (-423°F to 10°F).
Neurotoxicity
Administrative data
Description of key information
Data on main components of the Other Petroleum Gases category indicate members of the category show low sub-chronic and chronic toxicity and low potential for neurotoxicity. Inhalation exposure is the most relevant route. No significant exposure-related toxicological or neurotoxicological effects have been observed in inhalation studies up to 90 days duration on the C2-C4 alkanes or a category stream.
Key value for chemical safety assessment
Additional information
Repeat dose toxicity data with neurotoxicity assessments are available for the C2-C4 alkanes and one category stream material. Inhalation exposure is the most relevant route.
No systemic toxicity (i.e., no affect on survival, haematological or clinical chemistry parameters, food consumption, body weight, organ weight, and histopathology) or neurological effects (as measured by clinical observations, functional observational battery, and motor activity) were observed in 6-week studies to GLP-compliant guidelines in which ethane, propane, isobutane, butane and were administered to rats by inhalation. The NOAEC in all cases were the maximum dose levels tested (16000, 12000, 9000 and 9000 ppm respectively (equivalent to 19678, 21641, 21394 and 21394 mg/m3 respectively).
HLS (2009) report an OECD 414 study designed to assess the potential inhalation toxicity of liquefied petroleum gas (LPG, major components propane and propene) when administered via whole-body exposures to rats for 13 weeks. The assessment included routine toxicology parameters as well as detailed evaluations of neurotoxicity parameters. Rats were exposed to 0 (air control), 1000, 5000 or 10000 ppm of LPG, the highest exposure concentration was selected for safety reasons and approximated 50% of the lower explosive limit.
All animals (except one female animal exposed at the 10000 ppm level) survived to termination. There were no exposure-related differences in the test substance exposed animals compared to the air control animals. There were no treatment related effects on functional observational battery, motor activity parameters or neuropathology. The NOAEC was 10000 ppm.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
