Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: well-documented, non-guideline and non-GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1965
Report date:
1965

Materials and methods

Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl ether-boron trifluoride
EC Number:
206-532-1
EC Name:
Dimethyl ether-boron trifluoride
Cas Number:
353-42-4
Molecular formula:
C2H6BF3O
IUPAC Name:
(dimethyloxo)trifluoro-λ⁵-borane
Test material form:
other: liquid

Test animals

Species:
rabbit
Strain:
Vienna White

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
other: untreated skin of the same animal
Amount / concentration applied:
ca. 0.1 ml
Duration of treatment / exposure:
1 min, 5 min, 15 min, 20 h
Observation period:
8 days
Number of animals:
2

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: redness
Basis:
mean
Time point:
other: 1 min
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 8 days
Remarks on result:
other: reading 24 h
Irritation parameter:
other: scaliness
Basis:
mean
Time point:
other: 5 min
Score:
3
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Irritation parameter:
other: necrosis
Basis:
mean
Time point:
other: 15 min
Score:
3
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Irritation parameter:
other: necrosis
Basis:
mean
Time point:
other: 20 h
Score:
4
Max. score:
4
Reversibility:
not fully reversible within: 8 days
Remarks on result:
other: necrotic muscle on the dorsum and loss of 2/3 of the ear

Applicant's summary and conclusion

Interpretation of results:
highly corrosive
Remarks:
Migrated information