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EC number: 603-923-2 | CAS number: 135590-91-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on preparation and application of test substrate:
- - Method of mixing into soil:
For the preparation of the test substrates 740 g basic substrate for each concentration step were filled into a glass aquarium.
Each replicate for each concentration was mixed separately.To obtain a fresh stock mixture for the test, the test substance was weighed out to a precision of 0.1 mg and mixed in industrial sand. Defined amounts of stock mixture were added to the basic substrate in the mixing aquarium and well mixed with a rapid mixer . - Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: Earthworm
- Source: own culture
- Age at test initiation: older than 2 months
- Weight at test initiation: 372 mg (325 - 409 mg)
ACCLIMATION
- Acclimation period: 24 hours prior to testing the worms were taken from the culture and acclimatized to the test conditions in the freshly prepared basic substrate - Study type:
- laboratory study
- Substrate type:
- artificial soil
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Test temperature:
- 20 ± 1 °C
- pH:
- 6.4
- Moisture:
- 26.1 %
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 1.5 L glass jars,
- Amount of soil or substrate: 750 g of test substrate
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 4
- No. of replicates per control: 4
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
The artificial soil was prepared from:
- 10% (2.75 kg) dried and sifted sphagnum peat (residual
moisture content of 9.9 % taken into calculation)
- 20% (5.0kg) kaolin clay (type 1777, ziegler & Co., Wunsiedel,
FRG; kaolinite content 87.5%)
- 69.7% (17.4 kg) industrial sand (Quarzsand type 155-0,
Gebr. Willersinn GmbH & Co. KG, Ludwigshafen , FRG;
particle analysis: 40% 0.125 mm, 27% 0.09-0.125 mm,
13-15% 0.063 - 0.09 mm)
- 75 g Calcium carbonate (CaC03) were used to adjust the pH of this medium to 6.4.
OTHER TEST CONDITIONS
- Photoperiod: a 16-hour daylight photoperiod
- Light intensity: illuminated by wide spectrum fluorescent lights
EFFECT PARAMETERS MEASURED : The biomass of live worms was determined at the start and end of testing. Seven and 14 days after starting
the test, mortality and intoxication symptoms were recorded. - Nominal and measured concentrations:
- Limit dose of 1000 mg test item /kg dry substrate
- Reference substance (positive control):
- yes
- Remarks:
- chloroacetamide
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- > 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 000 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks:
- , weight gain, intoxication symptoms
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: 14-day LC50 value of 24.0 (18 – 32) mg /kg
Reference
Findings:
Soil substrate parameters such as moisture, pH and temperature were determined to be within the acceptable
limits. There was no mortality, intoxication symptoms and significant differences in weight loss and cocoon
production between 1000 mg/kg treatment and control groups. .
Conclusion:
In a 14-day Artificial Soil Test to determine the effects of AE F107892 technical on Eisenia fetida, the 14-day
LC50 was > 1000 mg/kg test item as no death occurred at this limit dose. In the absence of any sublethal findings
(intoxication symptoms, weight gain and intoxication symptoms) the NOEC 1000 mg/kg test item.
Description of key information
LC50 (14 d)>1000 mg/kg soil dw
Key value for chemical safety assessment
Additional information
The substance is not expected to pose a risk to soil macroorganisms. There is no indication for high adsorption or high persistence of the substance in soil. The determined log Pow of the substance is 4 and the adsorption potential is low (Koc range 486 – 823). Available tests on the biodegradation of the substance in soil determined half-lives of 7-13 days. Thus a long-term exposure of terrestrial organisms to substance is not likely. The substance is not acutely very toxic to aquatic organisms. All available effect concentrations (EC/LC50) are > 1 mg/L . Furthermore the available acute toxicity test conducted with earthworms determined no toxic effects of the substance. The study was conducted according to OECD guideline 207 (1991) using artificial soil as substrate. Earthworms of the species Eisenia fetida were exposed to a limit concentration of 1000 mg/kg. The artificial soil, prepared from a mixture of dried sphagnum peat, kaolin clay and industrial sand, was mixed with the test substance. No mortalities or symptoms of intoxication were observed. The determined 14-day LC50 was > 1000 mg/kg soil dw was no death occurred at this limit dose. In the absence of any sublethal findings (intoxication symptoms, weight gain and intoxication symptoms) the NOEC (14 d) was 1000 mg/kg soil dw. According to Annex IX, column 2 of Regulation (EC) No 1907/2006, chronic toxicity testing with soil macroorganisms does not need to be conducted as the Chemical Safety Assessment does not indicate a need for further investigations. According to Annex XI, Section 3 of Regulation (EC) No 1907/2006 toxicity tests on soil macroorganisms are considered not necessary. The exposure concentrations for the terrestrial compartment during the lifecycle of the substance are low. The environmental exposure assessment for the substance indicates no risk for the terrestrial compartment (all RCR< 1; please refer to Chapter 9 and 10 of the Chemical Safety Report for detailed information).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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