Registration Dossier
Registration Dossier
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EC number: 924-055-3 | CAS number: -
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Conclusions:
Exposure to rock wool fibers produced no interstitial fibrosis or neoplastic lesions at any time point.
Rock wool (stone wool) produced no fibrotic response or neoplasms.
These studies demonstrate that the inhalation of high levels of rock (stone) and slag wools, while causing nonspecific inflammatory lesions (rock and slag wool) and fibrosis with high lung burden of long fibers (rock wool only) in the lungs of exposed rats, showed no evidence of carcinogenic activity. These results suggest that respirable fractions of these MMVFs should not pose a significant health risk to humans at the relatively low airborne levels found in the workplace.
So are assessed to be not mutagenic.- Executive summary:
Long term inhalation studies prove that:
Exposure to rock wool fibers produced no interstitial fibrosis or neoplastic lesions at any time point.
Rock wool (stone wool) produced no fibrotic response or neoplasms.
These studies demonstrate that the inhalation of high levels of rock (stone) and slag wools, while causing nonspecific inflammatory lesions (rock and slag wool) and fibrosis with high lung burden of long fibers (rock wool only) in the lungs of exposed rats, showed no evidence of carcinogenic activity. These results suggest that respirable fractions of these MMVFs should not pose a significant health risk to humans at the relatively low airborne levels found in the workplace.
So are assessed to be not mutagenic.
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